The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHα3(IV)NC1 is associated with disease severity

子类 自身抗体 抗体 免疫学 A组 免疫球蛋白G 分布(数学) B组 医学 生物 分子生物学 内科学 数学 数学分析
作者
Juan Zhao,Yan Yu,Zhao Cui,Rui Yang,Minghui Zhao
出处
期刊:Human Immunology [Elsevier BV]
卷期号:70 (6): 425-429 被引量:54
标识
DOI:10.1016/j.humimm.2009.04.004
摘要

The current study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha3 chain [rHalpha3(IV)NC1]. Anti-GBM IgG1 could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 in groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the major subclasses with detectable IgG1; in group C, IgG1 became predominant and IgG3 was detectable; in group D, four IgG subclasses could be detected. In conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG1 and IgG3 may play a major role in the initiation and progression of the disease.
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