The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHα3(IV)NC1 is associated with disease severity

子类 自身抗体 抗体 免疫学 A组 免疫球蛋白G 分布(数学) B组 医学 生物 分子生物学 内科学 数学 数学分析
作者
Juan Zhao,Yan Yu,Zhao Cui,Rui Yang,Minghui Zhao
出处
期刊:Human Immunology [Elsevier BV]
卷期号:70 (6): 425-429 被引量:54
标识
DOI:10.1016/j.humimm.2009.04.004
摘要

The current study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha3 chain [rHalpha3(IV)NC1]. Anti-GBM IgG1 could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 in groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the major subclasses with detectable IgG1; in group C, IgG1 became predominant and IgG3 was detectable; in group D, four IgG subclasses could be detected. In conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG1 and IgG3 may play a major role in the initiation and progression of the disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
华仔应助怕孤单的破茧采纳,获得10
刚刚
2秒前
CipherSage应助672采纳,获得10
3秒前
dsjlove完成签到,获得积分20
4秒前
5秒前
等一只ya完成签到,获得积分10
5秒前
虚影完成签到,获得积分10
6秒前
伍铭完成签到 ,获得积分10
9秒前
俏皮的绝山完成签到,获得积分10
9秒前
9秒前
孙燕应助JIANGSHUI采纳,获得50
10秒前
唐禹嘉完成签到 ,获得积分10
11秒前
小超发布了新的文献求助10
14秒前
14秒前
科研通AI5应助YJ888采纳,获得10
15秒前
老干部完成签到,获得积分10
17秒前
随风完成签到,获得积分10
18秒前
19秒前
ycool完成签到 ,获得积分10
20秒前
21秒前
hxy123完成签到,获得积分10
21秒前
21秒前
ablesic.rong发布了新的文献求助10
23秒前
张绵羊完成签到 ,获得积分10
25秒前
香蕉觅云应助booooo采纳,获得10
25秒前
hxy123发布了新的文献求助10
25秒前
26秒前
22222发布了新的文献求助30
27秒前
辛辛应助来来采纳,获得10
28秒前
修辛发布了新的文献求助10
29秒前
30秒前
热心市民小红花应助bbh采纳,获得10
32秒前
ED应助机智太阳采纳,获得10
32秒前
臻灏完成签到,获得积分10
32秒前
英俊白莲完成签到,获得积分10
33秒前
33秒前
痴情的茈发布了新的文献求助10
33秒前
CHN完成签到 ,获得积分10
33秒前
34秒前
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989550
求助须知:如何正确求助?哪些是违规求助? 3531774
关于积分的说明 11254747
捐赠科研通 3270278
什么是DOI,文献DOI怎么找? 1804966
邀请新用户注册赠送积分活动 882125
科研通“疑难数据库(出版商)”最低求助积分说明 809176