Comparison of oral versus intravenous vitamin D receptor activator in reducing infection-related mortality in hemodialysis patients: the Q-Cohort Study

医学 血液透析 危险系数 内科学 队列研究 前瞻性队列研究 队列 比例危险模型 累积发病率 置信区间 外科
作者
Shigeru Tanaka,Toshiharu Ninomiya,Masatomo Taniguchi,Kiichiro Fujisaki,Masanori Tokumoto,Hideki Hirakata,Hiroaki Ooboshi,Takanari Kitazono,Kazuhiko Tsuruya
出处
期刊:Nephrology Dialysis Transplantation [Oxford University Press]
卷期号:31 (7): 1152-1160 被引量:23
标识
DOI:10.1093/ndt/gfw205
摘要

Hemodialysis patients who receive vitamin D receptor activator (VDRA) reportedly have better survival after infection than those who do not. However, the optimal route of its administration for minimizing death from infection remains unclear. This prospective cohort study aimed to compare the effectiveness of oral versus intravenous VDRA regarding infection-related mortality in 3372 hemodialysis patients. Eligible subjects were divided into the following three groups by route of administration of VDRA: oral (n = 1868), intravenous (n = 492) and not administered (n = 1012). The effect of VDRA on infection-related mortality was examined using a Cox regression model with propensity score-based adjustments. During follow-up (median, 4.0 years), 118 study patients died of infection. There was a significantly lower incidence of death from infection in subjects who received intravenous VDRA than in those who did not receive VDRA; however, oral VDRA did not significantly reduce the risk of mortality from infection compared with those who did not receive VDRA [hazard ratio (HR) for intravenous VDRA, 0.16; 95% confidence interval (CI), 0.10–0.25, and HR for oral VDRA, 0.78; 95% CI, 0.60–1.01]. Direct comparison between the oral and intravenous VDRA groups showed that the intravenous group had significantly better survival than the oral group (HR, 0.39; 95% CI, 0.27–0.62). Treatment with intravenous VDRA more effectively reduces the incidence of mortality from infection than oral VDRA in hemodialysis patients.
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