防御素
β防御素
脑脊液
免疫学
基因
阿尔茨海默病
疾病
生物
医学
遗传学
内科学
神经科学
作者
Márta Szekeres,Eszter Ivitz,Zsolt Datki,János Kálmán,Magdolna Pákáski,Zoltán Várhelyi,Peter Klivényi,Dénes Zádori,Ferenc Somogyvári,Zoltán Szolnoki,László Vécsei,Yvette Mándi
标识
DOI:10.1016/j.psychres.2016.03.045
摘要
The DEFB4 gene copy numbers were investigated in 206 AD patients and in 250 controls. The levels of the human defensin β−2 (hBD2) and α-defensins (HNP 1-3) in the sera and in the cerebrospinal fluid (CSF) of the patients and the controls were determined. Higher copy numbers of the DEFB4 gene was observed in AD patients as compared with the controls. The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients These data suggest that both defensin β−2 and α-defensins have potential role in the development of AD.
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