Central Precocious Puberty – Management and Long-term Outcomes

Central precocious puberty (CPP) results from premature re-activation of the gonadotropic axis. CPP is much more common in girls than in boys and is idiopathic in most cases. In boys, precocious puberty is more likely to be linked to hypothalamic lesions (≈40%). Recent studies have implicated the inactivation of MKRN3 gene in ‘idiopathic’ CPP. Gonadotropin-releasing hormone agonists are the standard treatment for progressive CPP.