生物粘附
自愈水凝胶
预聚物
角膜
材料科学
生物医学工程
光致聚合物
生物相容性材料
间质细胞
再生(生物学)
组织粘连
纳米技术
胶粘剂
医学
粘附
药物输送
聚合物
复合材料
眼科
聚合
高分子化学
病理
细胞生物学
生物
图层(电子)
聚氨酯
作者
Ehsan Shirzaei Sani,Ahmad Kheirkhah,Devyesh Rana,Zhongmou Sun,William Foulsham,Amir Sheikhi,Ali Khademhosseini,Reza Dana,Nasim Annabi
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2019-03-01
卷期号:5 (3)
被引量:229
标识
DOI:10.1126/sciadv.aav1281
摘要
Corneal injuries are common causes of visual impairment worldwide. Accordingly, there is an unmet need for transparent biomaterials that have high adhesion, cohesion, and regenerative properties. Herein, we engineer a highly biocompatible and transparent bioadhesive for corneal reconstruction using a visible light cross-linkable, naturally derived polymer, GelCORE (gel for corneal regeneration). The physical properties of GelCORE could be finely tuned by changing prepolymer concentration and photocrosslinking time. GelCORE revealed higher tissue adhesion compared to commercial adhesives. Furthermore, in situ photopolymerization of GelCORE facilitated easy delivery to the cornea, allowing for bioadhesive curing precisely according to the required geometry of the defect. In vivo experiments, using a rabbit stromal defect model, showed that bioadhesive could effectively seal corneal defects and induce stromal regeneration and re-epithelialization. Overall, GelCORE has many advantages including low cost and ease of production and use. This makes GelCORE a promising bioadhesive for corneal repair.
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