已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis

血小板 炎症 免疫学 炎症性肠病 促炎细胞因子 免疫系统 结肠炎 细胞生物学 生物 医学 疾病 病理
作者
Aaron C. Petrey,Dana R. Obery,Sean P. Kessler,Ash Zawerton,Bruno Flamion,Carol A. de la Motte
出处
期刊:Blood [American Society of Hematology]
卷期号:134 (9): 765-775 被引量:12
标识
DOI:10.1182/blood.2018893594
摘要

Abstract Platelets are specialized cells essential for hemostasis that also function as crucial effectors capable of mediating inflammatory and immune responses. These sentinels continually survey their environment and discriminate between homeostatic and danger signals such as modified components of the extracellular matrix. The glycosaminoglycan hyaluronan (HA) is a major extracellular matrix component that coats the vascular lumen and, under normal conditions, restricts access of inflammatory cells. In response to tissue damage, the endothelial HA matrix enhances leukocyte recruitment and regulates the early stages of the inflammatory response. We have shown that platelets can degrade HA from the surface of activated endothelial cells via the enzyme hyaluronidase-2 (HYAL2) and that HYAL2 is deficient in platelets isolated from patients with inflammatory bowel disease (IBD). Platelets are known to be involved in the pathogenesis of several chronic disease states, including IBD, but they have been largely overlooked in the context of intestinal inflammation. We therefore wanted to define the mechanism by which platelet HYAL2 regulates the inflammatory response during colitis. In this study, we provide evidence that HA catabolism is disrupted in human intestinal microvascular endothelial cells isolated from patients with IBD. Furthermore, mice deficient in HYAL2 are more susceptible to an acute model of colitis, and this increased susceptibility is abrogated by transfusion of HYAL2-competent platelets. Finally, we show that platelets, via HYAL2-dependent degradation of endothelial HA, regulate the early stages of inflammation in colitis by limiting leukocyte extravasation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
莎莎完成签到,获得积分20
2秒前
虚幻沛菡完成签到 ,获得积分10
9秒前
9秒前
11秒前
敏敏完成签到,获得积分10
12秒前
Cheny发布了新的文献求助10
14秒前
Qing完成签到,获得积分10
14秒前
Hello应助懵懂的朋友采纳,获得10
14秒前
16秒前
LiuShenglan完成签到,获得积分10
17秒前
Da完成签到,获得积分10
18秒前
pp完成签到,获得积分10
18秒前
18秒前
lili完成签到 ,获得积分10
18秒前
19秒前
海绵baobao完成签到,获得积分10
20秒前
21秒前
谷捣猫宁完成签到,获得积分10
21秒前
22秒前
22秒前
欧阳完成签到,获得积分10
22秒前
23秒前
调皮的土豆完成签到,获得积分10
23秒前
23秒前
诚心的安珊完成签到 ,获得积分10
24秒前
Autumnuer完成签到,获得积分20
24秒前
欧阳发布了新的文献求助10
25秒前
海绵baobao发布了新的文献求助10
27秒前
28秒前
kacey发布了新的文献求助10
28秒前
29秒前
小巧的中道完成签到,获得积分10
30秒前
丘比特应助kacey采纳,获得10
34秒前
无花果应助Cheny采纳,获得10
36秒前
VDC应助科研通管家采纳,获得10
46秒前
VDC应助科研通管家采纳,获得50
46秒前
寻道图强应助科研通管家采纳,获得30
46秒前
46秒前
寻道图强应助科研通管家采纳,获得30
46秒前
46秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162254
求助须知:如何正确求助?哪些是违规求助? 2813280
关于积分的说明 7899524
捐赠科研通 2472567
什么是DOI,文献DOI怎么找? 1316446
科研通“疑难数据库(出版商)”最低求助积分说明 631335
版权声明 602142