分散性
单体
共聚物
氨基酸
聚合
聚合物
高分子
化学
溶解度
高分子化学
氨基胺
手性(物理)
材料科学
组合化学
有机化学
树枝状大分子
物理
量子力学
生物化学
手征对称破缺
Nambu–Jona Lasinio模型
夸克
作者
Federica Ferruti,Jenny Alongi,Amedea Manfredi,Elisabetta Ranucci,Paolo Ferruti
出处
期刊:Polymers
[MDPI AG]
日期:2019-08-08
卷期号:11 (8): 1324-1324
被引量:5
标识
DOI:10.3390/polym11081324
摘要
Polyamidoamino acids (PAACs) are synthetic polymers prepared by the polyaddition of bisacrylamides with natural α-amino acids, which in the process maintain both their chirality and their amphoteric nature. This polymerization process is slow, but has the merits of taking place in water and of neither involving protection/de-protection steps nor releasing by-products. However, it leads to polydisperse polymers and, using α-amino acids mixtures, random copolymers. This paper presents a step-by-step polyaddition process leading to homo- and copolymeric PAACs with controlled sequences and controlled molecular weights. It exploits the much different rates of the two Michael addition steps of NH2 of α-amino acids with acrylamides, and the low solubility in organic solvents of the α-amino acid addition products. As a proof of principle, the controlled synthesis of the PAAC from l-arginine and N,N'-methylenebisacrylamide was performed up to a monodisperse product with 11 monomeric units and molecular weight 1840. This synthetic procedure was also tested with l-alanine. All intermediates were isolated and characterized. Noticeably, all of them were α,ω-difunctionalized with either acrylamides or sec-amines and were, in fact, building blocks with potential for preparing complex macromolecular architectures. In a first instance, copolymers with controlled sequences of amidoamine- and amidoamino acid units were prepared.
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