Chemical leak accidents not properly handled at the early stage can spread to major industrial disasters escalating through fire and explosion. Therefore, it is very important to develop a method that enables prompt and systematic response by identifying the location of leakage source quickly and accurately and informing on-site personnel of the probable location(s). In this study, a model that predicts the suspicious leak location(s) in real-time, using sensor data, is proposed. Feed-forward neural network and recurrent neural network with long short-term memory that learned the data gathered from the installed sensors are proposed to predict the Top-5 points in the order of highest likelihood. In order to train and verify the neural networks, the sensor data generated from computational fluid dynamics simulations for a real chemical plant are used. The model learns the inverse problem solving for accident scenarios and predicts the leak point with very high accuracy.