Acupuncture has been used in China for thousands of years and concerned as a typical alternative medicine in inflammatory diseases nowadays. The nuclear factor‐ κ B (NF‐ κ B) transcription factor is an important regulator of inflammation. In this article, we discuss the role of acupuncture in NF‐ κ B pathways and also present the acupoints selection, acupuncture administration, and related inflammation diseases and models from previous studies to bring readers close to a more complete understanding of the mechanisms between acupuncture and NF‐ κ B in inflammatory diseases.