医学
痛风
超声波
还原(数学)
内科学
放射科
几何学
数学
作者
Po‐Cheng Hung,D.-B. Lin,Amy Ker,Chieh-Chun Yang,Hung-Wan Chien,James Cheng‐Chung Wei
标识
DOI:10.1136/annrheumdis-2020-218846
摘要
With great interest, we read the article by Hammer et al reporting a treat-to-target (T2T) approach with urate-lowering treatment (ULT) resulted in significant reductions of crystal depositions via ultrasonic detection.1 We agree with the authors that the use of new semiquantitative scoring system may increase the sensitivity to minor changes in lesions in contrast to a binary scoring system. We would like, however, to highlight some key points.
First and foremost, there is no control group in this study. Although patients with gout have rapid reduction of crystal depositions by a T2T approach, we cannot tell how much of this improvement is due to the effect of the treatment itself. Moreover, whether the operators and the participants are blind or not is unknown in the article. A double-blind, controlled study is essential for giving information on effectiveness. Next, there are medicines left out, and a subgroup analysis for different treatment is required. …
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