Pathophysiological Functions of the lncRNA TUG1

表观遗传学 生物 下调和上调 疾病 基因 长非编码RNA 计算生物学 医学 生物信息学 遗传学 病理
作者
Chong Guo,Yuying Qi,Jiayuan Qu,Liyue Gai,Yue Shi,Chengfu Yuan
出处
期刊:Current Pharmaceutical Design [Bentham Science]
卷期号:26 (6): 688-700 被引量:58
标识
DOI:10.2174/1381612826666191227154009
摘要

Long non-coding RNAs (lncRNAs) with little or no coding capacity are associated with a plethora of cellular functions, participating in various biological processes. Cumulative study of lncRNA provides explanations to the physiological and pathological processes and new perspectives to the diagnosis, prevention, and treatment of some clinical diseases. Long non-coding RNA taurine-upregulated gene 1(TUG1) is one of the first identified lncRNAs associated with human disease, which actively involved in various physiological processes, including regulating genes at epigenetics, transcription, post-transcription, translation, and posttranslation. The aim of this review was to explore the molecular mechanism of TUG1 in various types of human diseases.In this review, we summarized and analyzed the latest findings related to the physiologic and pathophysiological processes of TUG1 in human diseases. The related studies were retrieved and selected the last six years of research articles in PubMed with lncRNA and TUG1 as keywords.TUG1 is a valuable lncRNA that its dysregulated expression and regulating the biological processes were found in a variety of human diseases. TUG1 is found to exhibit aberrant expression in a variety of malignancies. Dysregulation of TUG1 has been shown to contribute to proliferation, migration, cell cycle changes, inhibited apoptosis, and drug resistance of cancer cells, which revealed an oncogenic role for this lncRNA, but some reports have shown downregulation of TUG1 in lung cancer samples compared with noncancerous samples. In addition, the molecular and biological functions of TUG1 in physiology and disease (relevant to endocrinology, metabolism, immunology, neurobiology) have also been highlighted. Finally, we discuss the limitations and tremendous diagnostic/therapeutic potential of TUG1 in cancer and other diseases.Long non-coding RNA-TUG1 likely served as useful disease biomarkers or therapy targets and effectively applied in different kinds of diseases, such as human cancer and cardiovascular diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Warren发布了新的文献求助10
刚刚
1秒前
可爱的函函应助赵康康采纳,获得10
2秒前
colddie完成签到,获得积分10
2秒前
dwl完成签到 ,获得积分10
3秒前
不许内耗完成签到,获得积分10
3秒前
4秒前
4秒前
嗯哼应助优秀的小兔子采纳,获得10
6秒前
6秒前
kevin发布了新的文献求助10
8秒前
方知有发布了新的文献求助10
8秒前
静汉完成签到,获得积分20
9秒前
在水一方应助热心兰采纳,获得10
10秒前
11秒前
Hello应助淮安重午采纳,获得10
11秒前
12秒前
亦玉发布了新的文献求助10
12秒前
13秒前
13秒前
wang完成签到,获得积分20
15秒前
Warren完成签到,获得积分20
15秒前
15秒前
16秒前
方知有完成签到,获得积分20
17秒前
19秒前
金枪鱼子发布了新的文献求助10
19秒前
阿莫西林发布了新的文献求助10
19秒前
wang发布了新的文献求助10
20秒前
搞怪藏今发布了新的文献求助10
21秒前
21秒前
桃博完成签到,获得积分10
22秒前
深情安青应助nnnd77采纳,获得10
23秒前
24秒前
沉默完成签到,获得积分10
25秒前
聪慧千亦发布了新的文献求助10
26秒前
葡萄成熟发布了新的文献求助10
27秒前
DIDIDI完成签到 ,获得积分10
27秒前
不许内耗发布了新的文献求助10
28秒前
风中盼易发布了新的文献求助10
29秒前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Basic Modern Theory of Linear Complex Analytic 𝑞-Difference Equations 510
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3059008
求助须知:如何正确求助?哪些是违规求助? 2714902
关于积分的说明 7443217
捐赠科研通 2360428
什么是DOI,文献DOI怎么找? 1250724
科研通“疑难数据库(出版商)”最低求助积分说明 607512
版权声明 596432