[Clinical and imaging characteristics of 110 patients with infectious sacroiliitis].

Objective: To investigate the clinical and imaging characteristics of infectious sacroiliitis. Methods: A total of 110 patients diagnosed with infectious sacroiliitis were retrospectively analyzed between 2008 and 2017.Clinical manifestations and therapeutic responses, laboratory tests such as HLA-B(27), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), T cell spot test for tuberculosis infection(TB-SPOT), Brucella agglutination test ect., blood culture of pathogens, pathological findings as well as magnetic resonance imaging were all recorded and analyzed. Results: Among the 110 patients, the male to female ratio was 44 to 66 with an average age 15-58(29.4±10.8) years and the course of disease 0.3-60 (5.7±13.2) months. As to the pathogens, 71 cases were pyogenic, 24 cases with tuberculous sacroiliitis, and 15 cases were brucellosis infections. The majority of patients (97.3%) had unilateral sacroiliac joint involvement. Ten (9.1%) patients suffered infectious sacroiliac arthritis after delivery. Hip pain was the main clinical manifestation (83/110,75.5%) and fever as the second (77/110,70.0%). HLA-B(27) was positive in 11 patients (10.0%). Both ESR and CRP were elevated in the majority. There were 103 patients receiving sacroiliac joint puncture biopsy. Seven patients were diagnosed through blood culture or brucellosis agglutination test. Bone marrow edema and osteolytic lesions in magnetic resonance imaging (MRI) were more common in pyogenic or tuberculous sacroiliitis than in brucellosis infections. Conclusion: Infectious sacroiliitis should be differentiated from spondyloarthritis, which develops more in female patients, with short disease duration and fever, mostlynegative HLA-B(27). The majority patients present unilateral sacroiliitis. Active inflammatory lesions are usually beyond sacroiliac joints with osteolytic changes in MRI examinations.目的： 通过分析感染性骶髂关节炎的临床及影像学特点，旨在提高临床医生对其的认识水平，避免误诊误治。 方法： 回顾性分析2008年1月—2017年12月解放军总医院第一医学中心风湿科收治的110例感染性骶髂关节炎患者的一般临床资料（包括主要临床表现、伴随症状、治疗反应）、实验室检查[包括人类白细胞表面抗原（HLA）-B(27)、红细胞沉降率、C反应蛋白、结核感染T细胞检测、布鲁菌凝集试验]、血培养（包括细菌、真菌、抗酸杆菌、布鲁菌）、磁共振成像及病理学特点。 结果： 110例感染性骶髂关节炎患者，男性44例，女性66例，年龄15~58（29.4±10.8）岁，病程10 d~60（5.7±13.2）个月。其中化脓性骶髂关节炎71例，结核性骶髂关节炎24例，布鲁菌感染骶髂关节炎15例。107例（97.3%）患者骶髂关节受累为单侧，10例（9.1%）为分娩后出现的感染性骶髂关节炎。83例（75.5%）患者以臀区痛为主要临床表现，77例（70.0%）有发热。11例（10.0%）HLA-B(27)阳性，100例（91.0%）患者红细胞沉降率和C反应蛋白升高。110例患者中103例患者行骶髂关节穿刺活检明确感染性骶髂关节炎的诊断；7例未行骶髂关节穿刺活检者2例血培养布鲁菌阳性；5例布鲁菌凝集试验阳性明确诊断。化脓性骶髂关节炎和结核性骶髂关节炎MRI示骨髓水肿和骨侵蚀较布鲁菌感染骶髂关节炎更明显。 结论： 感染性骶髂关节炎易与脊柱关节炎相混淆，但本病女性患病较高，病程时间较短，HLA-B(27)阴性为主，并伴有发热；多为单侧骶髂关节炎；骶髂关节MRI见活动性炎症病变较明显，炎症范围多超出骶髂关节解剖结构，并有骨侵蚀的表现。因此了解其临床及影像学特征可降低误诊率。.