清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Bilateral single-injection erector spinae plane block versus intrathecal morphine for postoperative analgesia in living donor laparoscopic hepatectomy: a randomized non-inferiority trial

医学 罗哌卡因 麻醉 呕吐 恶心 术后恶心呕吐 随机对照试验 止痛药 吗啡 肝切除术 外科 切除术
作者
RyungA Kang,Ki Jinn Chin,Mi Sook Gwak,Gaab Soo Kim,Soo Joo Choi,Jong Man Kim,Gyu‐Seong Choi,Justin Sangwook Ko
出处
期刊:Regional Anesthesia and Pain Medicine [BMJ]
卷期号:: rapm-100902 被引量:41
标识
DOI:10.1136/rapm-2019-100902
摘要

Background Intrathecal morphine (ITM) provides effective postoperative analgesia in living donor hepatectomy but has significant adverse effects. Studies support the efficacy of erector spinae plane (ESP) blocks in laparoscopic abdominal surgery; we therefore hypothesized that they would provide non-inferior postoperative analgesia compared with ITM and reduce postoperative nausea/vomiting and pruritus. We conducted a randomized, controlled, non-inferiority trial to compare the analgesic efficacy of ITM and bilateral single-injection ESP blocks in laparoscopic donor hepatectomy. Methods Fifty-four donors were randomized to receive bilateral ESP blocks with 20 mL 0.5% ropivacaine (n=27) or 400 µg ITM (n=27). Primary outcome was resting pain score 24 hours postoperatively measured on an 11-point numeric rating scale. The prespecified non-inferiority limit was 1. Incidences of postoperative nausea/vomiting and pruritus were assessed. Results The mean treatment difference (ESP–ITM) in the primary outcome was 1.2 (95% CI 0.7 to 1.8). The 95% CI upper limit exceeded the non-inferiority limit. Opioid consumption and all other pain measurements were similar between groups up to 72 hours postoperatively. The ESP group had significantly lower incidences of postoperative vomiting (p=0.002) and pruritus (p<0.001). Conclusions Bilateral single-injection ESP blocks resulted in higher resting pain scores 24 hours postoperatively compared with ITM and thus did not meet the study definition of non-inferiority. However, the pain intensity with ESP blocks was mild (mean pain scores <3/10) and associated with reduced incidence of postoperative vomiting and pruritus. It warrants further investigation as an analgesic option after laparoscopic living donor hepatectomy. Trial registration number KCT0003191.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Benhnhk21完成签到,获得积分10
15秒前
赘婿应助无限的以亦采纳,获得10
17秒前
偷得浮生半日闲完成签到,获得积分10
18秒前
Yan完成签到 ,获得积分10
23秒前
某某某完成签到,获得积分10
29秒前
龙王爱吃糖完成签到 ,获得积分10
34秒前
zhang完成签到 ,获得积分10
38秒前
rafa完成签到 ,获得积分10
39秒前
龙猫爱看书完成签到,获得积分10
49秒前
无为完成签到 ,获得积分10
49秒前
54秒前
1分钟前
坚强的铅笔完成签到 ,获得积分10
1分钟前
王敏完成签到 ,获得积分10
1分钟前
32429606完成签到 ,获得积分10
1分钟前
1分钟前
想游泳的鹰完成签到,获得积分10
1分钟前
1分钟前
1分钟前
六一儿童节完成签到 ,获得积分10
1分钟前
Una完成签到,获得积分10
1分钟前
Dong完成签到 ,获得积分10
1分钟前
史克珍香完成签到 ,获得积分10
1分钟前
huanghe完成签到,获得积分10
1分钟前
取法乎上完成签到 ,获得积分10
1分钟前
徐团伟完成签到 ,获得积分10
1分钟前
不辣的完成签到 ,获得积分10
2分钟前
扶我起来写论文完成签到 ,获得积分10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
红茸茸羊完成签到 ,获得积分10
2分钟前
属实有点拉胯完成签到 ,获得积分10
2分钟前
2分钟前
DduYy完成签到,获得积分10
2分钟前
朴实乐天完成签到,获得积分10
2分钟前
跳跃的鹏飞完成签到 ,获得积分10
2分钟前
小悟空的美好年华完成签到 ,获得积分10
2分钟前
RYAN完成签到 ,获得积分10
2分钟前
Ray完成签到 ,获得积分10
2分钟前
3分钟前
Balance Man完成签到 ,获得积分10
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968532
求助须知:如何正确求助?哪些是违规求助? 3513358
关于积分的说明 11167309
捐赠科研通 3248700
什么是DOI,文献DOI怎么找? 1794453
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804664