绿色荧光蛋白
荧光
化学
纳米技术
生物物理学
合理设计
发色团
光化学
材料科学
生物化学
生物
量子力学
基因
物理
作者
Jia Kong,Yuefei Wang,Wei Qi,Ming Huang,Rongxin Su,Zhimin He
标识
DOI:10.1016/j.cis.2020.102286
摘要
Green fluorescence proteins (GFP) are appealing to a variety of biomedical and biotechnology applications, such as protein fusion, subcellular localizations, cell visualization, protein-protein interaction, and genetically encoded sensors. To mimic the fluorescence of GFP, various compounds, such as GFP chromophores analogs, hydrogen bond-rich proteins, and aromatic peptidyl nanostructures that preclude free rotation of the aryl-alkene bond, have been developed to adapt them for a fantastic range of applications. Herein, we firstly summarize the structure and luminescent mechanism of GFP. Based on this, the design strategy, fluorescent properties, and the advanced applications of GFP-inspired fluorophores are then carefully discussed. The diverse advantages of bioinspired fluorophores, such as biocompatibility, structural simplicity, and capacity to form a variety of functional nanostructures, endow them potential candidates as the next-generation bio-organic optical materials.
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