Application of CT-based radiomics in predicting portal pressure and patient outcome in portal hypertension

医学 门脉高压 无线电技术 放射科 门静脉压 队列 静脉曲张 内科学 肝硬化
作者
Yujen Tseng,Lili Ma,Shaobo Li,Tiancheng Luo,Jianjun Luo,Wen Zhang,Jian Wang,Shiyao Chen
出处
期刊:European Journal of Radiology [Elsevier BV]
卷期号:126: 108927-108927 被引量:16
标识
DOI:10.1016/j.ejrad.2020.108927
摘要

Purpose Portal venous pressure (PVP) measurement is of clinical significance, especially in patients with portal hypertension. However, the invasive nature and associated complications limits its application. The aim of the study is to propose a noninvasive predictive model of PVP values based on CT-extracted radiomic features. Methods Radiomics PVP (rPVP) models based on liver, spleen and combined features were established on an experimental cohort of 169 subjects. Radiomics features were extracted from each ROI and reduced via the LASSO regression to achieve an optimal predictive formula. A validation cohort of 62 patients treated for gastroesophageal varices (GOV) was used to confirm the utility of rPVP in predicting variceal recurrence. The association between rPVP and response to treatment was observed. Results Three separate predictive formula for PVP were derived from radiomics features. rPVP was significantly correlated to patient response to endoscopic treatment for GOV. Among which, the model containing both liver and spleen features has the highest predictability of variceal recurrence, with an optimal cut-off value at 29.102 mmHg (AUC 0.866). A Kaplan Meier analysis further confirmed the difference between patients with varying rPVP values. Conclusion PVP values can be accurately predicted by a non-invasive, CT derived radiomics model. rPVP serves as a non-invasive and precise reference for predicting treatment outcome for GOV secondary to portal hypertension.
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