乳腺癌
医学
癌症
循环肿瘤细胞
癌症生物标志物
乳腺摄影术
生物标志物
癌症筛查
疾病
肿瘤科
生物标志物发现
内科学
病理
液体活检
生物信息学
生物
转移
蛋白质组学
基因
生物化学
作者
Jiawei Li,Xin Guan,Zhimin Fan,Lai‐Ming Ching,Yan Li,Xiaojia Wang,Wen‐Ming Cao,Dong‐Xu Liu
出处
期刊:Cancers
[MDPI AG]
日期:2020-09-27
卷期号:12 (10): 2767-2767
被引量:143
标识
DOI:10.3390/cancers12102767
摘要
Breast cancer is the most common cancer in women worldwide. Accurate early diagnosis of breast cancer is critical in the management of the disease. Although mammogram screening has been widely used for breast cancer screening, high false-positive and false-negative rates and radiation from mammography have always been a concern. Over the last 20 years, the emergence of “omics” strategies has resulted in significant advances in the search for non-invasive biomarkers for breast cancer diagnosis at an early stage. Circulating carcinoma antigens, circulating tumor cells, circulating cell-free tumor nucleic acids (DNA or RNA), circulating microRNAs, and circulating extracellular vesicles in the peripheral blood, nipple aspirate fluid, sweat, urine, and tears, as well as volatile organic compounds in the breath, have emerged as potential non-invasive diagnostic biomarkers to supplement current clinical approaches to earlier detection of breast cancer. In this review, we summarize the current progress of research in these areas.
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