Effect of visit-to-visit LDL-, HDL-, and non-HDL-cholesterol variability on mortality and cardiovascular outcomes after percutaneous coronary intervention

医学 内科学 经皮冠状动脉介入治疗 传统PCI 混淆 心脏病学 心肌梗塞 冲程(发动机) 高密度脂蛋白 胆固醇 机械工程 工程类
作者
Eun Young Lee,Yeoree Yang,Hun‐Sung Kim,Jae‐Hyoung Cho,Kun‐Ho Yoon,Wook Sung Chung,Seung‐Hwan Lee,Kiyuk Chang
出处
期刊:Atherosclerosis [Elsevier BV]
卷期号:279: 1-9 被引量:53
标识
DOI:10.1016/j.atherosclerosis.2018.10.012
摘要

Abstract

Background and aims

Visit-to-visit variability in biological measures has been suggested as an independent predictor of cardiovascular disease (CVD). Although low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) are important risk factors of CVD, there are few studies investigating the effect of variability in LDL-C and HDL-C on cardiovascular outcomes. We investigated the association between visit-to-visit variability in LDL-C, HDL-C, and non-HDL-C and major adverse cardiovascular and cerebrovascular events (MACCE) in patients who underwent percutaneous coronary intervention (PCI).

Methods

Data from 1792 subjects who underwent PCI from January 2004 to December 2009 were analyzed. Visit-to-visit variability was calculated using various indices: standard deviation (SD), coefficient of variation, and corrected variability independent of mean (cVIM). MACCE comprised all-cause death, non-fatal myocardial infarction, and stroke.

Results

During a median follow-up period of 65 months, 114 subjects (6.4%) experienced MACCE: 68 (3.8%) all-cause death; 43 (2.4%) stroke, and 15 (0.8%) non-fatal myocardial infarction. Visit-to-visit variability in LDL-C, HDL-C, and non-HDL-C was significantly higher in the MACCE group compared to the non-MACCE group. In multiple regression analysis, all LDL-C, HDL-C, and non-HDL-C variability parameters were independent predictors for MACCE after adjusting for potential confounding factors. Each 1-SD increase of cVIM in LDL-C, HDL-C, and non-HDL-C increased the risk of MACCE by 34% (HR 1.34 [95% CI, 1.18–1.52]), 50% (HR 1.50 [95% CI 1.32–1.71]), and 37% (HR 1.37 [95% CI, 1.20–1.57]), respectively. These relationships were observed in various subgroups according to age, sex, and diabetes status.

Conclusions

Visit-to-visit variability in LDL-C, HDL-C, and non-HDL-C is associated with MACCE in subjects with previous PCI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
白小胖完成签到,获得积分10
刚刚
嘻嘻丹儿完成签到,获得积分10
1秒前
再也不拖发布了新的文献求助10
1秒前
李珂完成签到,获得积分10
1秒前
Hello应助内向寒云采纳,获得10
1秒前
NK0072完成签到,获得积分10
1秒前
1秒前
小榕完成签到,获得积分10
1秒前
CodeCraft应助yukie采纳,获得10
1秒前
善学以致用应助km采纳,获得30
1秒前
Graham完成签到 ,获得积分10
2秒前
香查朵完成签到,获得积分10
2秒前
大米完成签到,获得积分10
2秒前
3秒前
3秒前
Kane完成签到,获得积分10
3秒前
方文琛完成签到,获得积分10
3秒前
乐乐应助song采纳,获得10
3秒前
4秒前
yar给凪白的求助进行了留言
4秒前
科研通AI2S应助hqq采纳,获得10
4秒前
777完成签到,获得积分10
5秒前
5秒前
rock发布了新的文献求助10
5秒前
灰灰完成签到,获得积分10
6秒前
6秒前
阿俊完成签到 ,获得积分10
6秒前
7秒前
shan完成签到,获得积分10
8秒前
趣乐多给趣乐多的求助进行了留言
8秒前
李健的小迷弟应助落落采纳,获得10
8秒前
灰原哀发布了新的文献求助10
10秒前
焦糖泡芙塔完成签到,获得积分10
11秒前
李健的小迷弟应助LaInh采纳,获得10
11秒前
zshhay发布了新的文献求助10
12秒前
FashionBoy应助再也不拖采纳,获得10
13秒前
13秒前
14秒前
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970287
求助须知:如何正确求助?哪些是违规求助? 3515034
关于积分的说明 11176923
捐赠科研通 3250301
什么是DOI,文献DOI怎么找? 1795244
邀请新用户注册赠送积分活动 875732
科研通“疑难数据库(出版商)”最低求助积分说明 805039