袋3
热休克蛋白
WW域
调节器
生物
伴侣(临床)
细胞生物学
心功能曲线
蛋白质折叠
基因
计算生物学
生物信息学
遗传学
医学
心力衰竭
内科学
自噬
病理
细胞凋亡
作者
Xi Fang,Julius Bogomolovas,Christa Trexler,Ju Chen
出处
期刊:JCI insight
[American Society for Clinical Investigation]
日期:2019-02-21
卷期号:4 (4)
被引量:20
标识
DOI:10.1172/jci.insight.126464
摘要
Small heat shock proteins (sHSPs) comprise an important protein family that is ubiquitously expressed, is highly conserved among species, and has emerged as a critical regulator of protein folding. While these proteins are functionally important for a variety of tissues, an emerging field of cardiovascular research reveals sHSPs are also extremely important for maintaining normal cardiac function and regulating the cardiac stress response. Notably, numerous mutations in genes encoding sHSPs have been associated with multiple cardiac diseases. sHSPs (HSPB5, HSPB6, and HSPB8) have been described as mediating chaperone functions within the heart by interacting with the cochaperone protein BCL-2-associated anthanogene 3 (BAG3); however, recent reports indicate that sHSPs (HSPB7) can perform other BAG3-independent functions. Here, we summarize the cardiac functions of sHSPs and present the notion that cardiac sHSPs function via BAG3-dependent or -independent pathways.
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