糖基化
脐静脉
化学
氧化应激
咖啡酸
糖基化终产物
炎症
内皮功能障碍
生物化学
抗氧化剂
体外
药理学
内科学
免疫学
医学
受体
作者
Xiangyu Cao,Ying Xia,Meng Zeng,Weiyu Wang,Yin He,Jianli Liu
标识
DOI:10.1002/cbdv.201900174
摘要
Abstract The advanced glycation end products (AGEs) are the compounds produced by non‐enzymatic glycation reaction of proteins and sugars, which can induce the generation of free radicals and the expression of inflammatory factors, thereby playing an important role in vascular dysfunction in diabetes. To investigate the effects of caffeic acid (CA) on glycation formed by glucose and protein, various spectroscopic techniques and molecular docking methods were carried out. Furthermore, the protective effects of CA on human umbilical vein endothelial cells (HUVECs) damaged by AGEs were detected. The results indicated that CA inhibited AGEs formation in vitro, decreased the expression of IL‐1 β , IL‐18, ICAM‐1, VCAM‐1, NLRP3, Caspase‐1 and CRP (C‐reactive protein) and reduced the ROS in HUVECs exposed to AGEs. Our findings suggested that the supplementation with dietary CA could prevent and delay the AGEs‐induced vascular dysfunction in diabetes.
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