ORMDL3 and its implication in inflammatory disorders

Abstract A growing body of evidence has suggested the genetic association of ORMDL 3 gene ( ORMDL Sphingolipid Biosynthesis Regulator 3 ) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL 3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL 3 gene expression in inflammation. This mini‐review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL 3 in common inflammatory disorders.