Association of platelet-derived microvesicles and their phenotypes with carotid atherosclerosis and recurrent vascular events in patients after ischemic stroke

医学 冲程(发动机) 心脏病学 内科学 促炎细胞因子 川地31 内膜中层厚度 颈总动脉 血小板 病理 炎症 颈动脉 血管生成 机械工程 工程类
作者
Justyna Rosińska,Wojciech Ambrosius,Joanna Maciejewska,Robert Narożny,Wojciech Kozubski,Maria Łukasik
出处
期刊:Thrombosis Research [Elsevier BV]
卷期号:176: 18-26 被引量:20
标识
DOI:10.1016/j.thromres.2019.01.014
摘要

Platelet-derived microvesicles (pMVs) exhibit procoagulant and proinflammatory properties and play a role in the development and progression of atherosclerosis. The study examined the association between the total number of pMVs and their phenotypes with carotid atherosclerosis and recurrent vascular events (VEs) in patients in the convalescent phase of ischemic stroke (IS).The study group consisted of 72 patients with IS secondary to large artery atherosclerosis (LAA) (n = 40) and small arteries occlusion (SAO) (n = 32) and 69 matched cardiovascular disease risk-factor (RF) controls. Total pMV number, defined as CD61+ microvesicles (MVs), and their phenotypes, defined as the surface expression of proinflammatory (CD40L, CD62P, CD31) and procoagulant (PS, PAC-1) markers, were characterized and quantified using flow cytometry. The mean common carotid intima-media thickness (CCA mean IMT), maximal common carotid IMT (CCA max IMT) and maximal bifurcation IMT (BIF max IMT) were measured bilaterally using B-mode, color Doppler ultrasonography. All study subjects were observed for one-year to establish the occurrence of VEs.No differences in pMV parameters between LAA and SAO stroke subjects and between stroke subgroups and controls were found. Stroke patients with carotid atherosclerosis exhibited higher concentration of CD62P+/CD61+ and PAC-1+/CD61+ MVs compared to patients without the atherosclerosis. Positive associations between total number of pMVs, AnV+ MVs and AnV+/CD61+ MVs and atherosclerotic thickening of carotid intima-media in stroke patients were found. Elevated concentration of AnV+/CD61+, PAC-1+/CD61+, CD61P+/CD61+ and CD31+/CD61+ MVs, were revealed in stroke patients who suffered from recurrent VE in one-year follow-up period. Negative correlation of pMVs and CD62P+/CD61+ MVs concentration as well as percentage of total CD61+ in AnV+ population of MVs and time elapsed from IS in convalescent stroke subjects was revealed.Our results confirm positive correlations between total pMV number, the number of PAC-1+/CD61+ and CD62+/CD61+ MVs and carotid atherosclerosis in stroke subjects. Some pMV parameters may exhibit a predictive value for the next VE in groups with a history of stroke. pMVs and some of their phenotypes decline over time elapsed from stroke in convalescent stroke subjects.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
can完成签到,获得积分10
刚刚
zhongzihao完成签到,获得积分20
1秒前
小蘑菇应助MaYue采纳,获得10
1秒前
1秒前
孙福禄应助机智的然然采纳,获得10
1秒前
GooJohn发布了新的文献求助10
2秒前
NexusExplorer应助杜兰特工队采纳,获得10
3秒前
3秒前
3秒前
4秒前
FashionBoy应助鲤跃采纳,获得10
5秒前
阳光c完成签到 ,获得积分10
5秒前
威武的手链完成签到,获得积分20
6秒前
sxr完成签到,获得积分10
6秒前
zhongzihao发布了新的文献求助10
7秒前
7秒前
在水一方应助闪闪采纳,获得10
7秒前
Jay发布了新的文献求助10
8秒前
灰灰子发布了新的文献求助10
8秒前
量子星尘发布了新的文献求助10
9秒前
9秒前
小丑鱼儿发布了新的文献求助10
11秒前
XYN1发布了新的文献求助10
11秒前
14秒前
14秒前
LiuLiu完成签到,获得积分10
15秒前
樱桃小热巴完成签到 ,获得积分10
15秒前
16秒前
16秒前
不低头完成签到,获得积分10
16秒前
大鱼完成签到,获得积分10
17秒前
17秒前
XYN1完成签到,获得积分10
17秒前
MaYue发布了新的文献求助10
18秒前
18秒前
18秒前
闪闪发布了新的文献求助10
19秒前
尊敬依珊发布了新的文献求助10
20秒前
强强完成签到,获得积分10
21秒前
阿童木发布了新的文献求助10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035