化学
对映选择合成
取代基
不对称氢化
配体(生物化学)
组合化学
Noyori不对称加氢
手性配体
催化加氢
催化作用
有机化学
生物化学
受体
作者
Chao Li,Jianzhong Chen,Guanghong Fu,Delong Liu,Yangang Liu,Wanbin Zhang
出处
期刊:Tetrahedron
[Elsevier]
日期:2013-08-01
卷期号:69 (33): 6839-6844
被引量:56
标识
DOI:10.1016/j.tet.2013.06.016
摘要
(S)-C10–BridgePHOS was successfully applied to a highly efficient Pd-catalyzed enantioselective hydrogenation of substituted indoles. The methodology was suitable for the hydrogenation of indoles substituted at the 2-, 3- and 2,3-positions. Products were obtained in quantitative conversion and up to 98% ee. The role the 2-position substituent plays in the hydrogenation process has been proposed. The methodology could be used as an alternative method to synthesize extremely important chiral indolines from N-unprotected indoles.
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