Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) as a Mild Deoxofluorination Reagent

The solid, air-stable peptide coupling reagent TFFH (tetramethylfluoroformamidinium hexafluorophosphate) was found to activate a variety of alcohols towards deoxofluorination. These conditions are compatible with carbonyl functional groups thus offering interesting possibilities for the application to sensitive molecules.