甲基丙烯酰胺
明胶
高分子化学
甲基丙烯酸酯
化学
水解
水溶液
聚合
共聚物
聚合物
有机化学
丙烯酰胺
作者
Jing Zheng,Mengxiang Zhu,Gaia Ferracci,Nam‐Joon Cho,Bae Hoon Lee
标识
DOI:10.1002/macp.201800266
摘要
Abstract Gelatin methacryloyl (GelMA; GM) is a promising nature‐derived photocurable material that can mimic the extracellular matrix because GelMA features tailorable mechanical properties, proteolytic degradation, and good cell adhesion. GelMA contains not only methacrylamide but also methacrylate. However, the hydrolytic stability of methacrylamide and methacrylate groups of GelMA in aqueous solutions has not been scrutinized. Here, the structural change of GelMA through hydrolysis is investigated for the first time. The structural change of hydrolyzed GelMA is quantitatively identified using colorimetric and 1 H NMR methods. The methacrylate groups decompose markedly at high pH solutions, but the methacrylamide groups remain stable. Further, pure gelatin methacrylamide is successfully decoupled from GelMA for a better understanding of GelMA structure and future use for biomedical applications.
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