已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Neurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study

重性抑郁障碍 白质 心理学 双相情感障碍 磁共振弥散成像 磁共振成像 精神分裂症(面向对象编程) 神经科学 大脑大小 神经影像学 精神科 医学 认知 放射科
作者
Miao Chang,Fay Y. Womer,E. Kale Edmiston,Chuan Bai,Qian Zhou,Xiaowei Jiang,Shengnan Wei,Yange Wei,Yuting Ye,Haiyan Huang,Yong He,Ke Xu,Yanqing Tang,Fei Wang
出处
期刊:Schizophrenia Bulletin [Oxford University Press]
卷期号:44 (1): 65-74 被引量:78
标识
DOI:10.1093/schbul/sbx028
摘要

Background: Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site. Results: Significant 4-group (SZ, BD, MDD, and HC groups) differences (P < .05, corrected) in GM volumes were found primarily in the paralimbic and heteromodal corticies. Post hoc analyses showed that the SZ, BD, and MDD groups shared GM volume decreases in 87.9% of the total regional volume with significant 4-group differences. Significant 4-group differences in WM integrity (P < .05 corrected) were found in callosal, limbic-paralimbic-hetermodal, cortico-cortical, thalamocortical and cerebellar WM. Post hoc analyses revealed that the SZ and BD groups shared WM alterations in all regions, while WM alterations were not observed with MDD. Conclusions: Our findings of common alterations in SZ, BD, and MDD support the presence of core neurobiological disruptions in these disorders and suggest that neural structural distinctions between these disorders may be less prominent than initially postulated, particularly between SZ and BD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
hhllhh发布了新的文献求助10
1秒前
负责怀莲发布了新的文献求助10
2秒前
慕容半邪完成签到,获得积分10
3秒前
冰兰完成签到,获得积分10
4秒前
4秒前
Jing关注了科研通微信公众号
7秒前
乐糖完成签到 ,获得积分10
9秒前
斐嘿嘿发布了新的文献求助10
9秒前
小桐完成签到,获得积分10
10秒前
陌上花开完成签到,获得积分0
11秒前
yuan完成签到,获得积分10
14秒前
Arui发布了新的文献求助10
15秒前
wanci应助谨慎哈密瓜采纳,获得10
18秒前
18秒前
SciGPT应助平淡的乐曲采纳,获得30
19秒前
mw完成签到,获得积分10
20秒前
hyhyhyhy发布了新的文献求助10
23秒前
乐乐应助hhllhh采纳,获得10
23秒前
yumiao发布了新的文献求助10
24秒前
小橙子完成签到,获得积分10
25秒前
Mtx3098520564完成签到 ,获得积分10
25秒前
FF完成签到 ,获得积分10
26秒前
34秒前
陈军应助雪山飞鹰采纳,获得10
35秒前
sky发布了新的文献求助10
35秒前
谨慎哈密瓜完成签到,获得积分10
37秒前
39秒前
40秒前
Yuson_L发布了新的文献求助10
41秒前
hhllhh发布了新的文献求助10
42秒前
儒雅南风发布了新的文献求助10
42秒前
43秒前
43秒前
负责怀莲发布了新的文献求助10
46秒前
47秒前
看不了一点文献应助lzm采纳,获得20
49秒前
852应助mpenny77采纳,获得30
50秒前
眨眼发布了新的文献求助10
53秒前
53秒前
SUE关闭了SUE文献求助
57秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989857
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255679
捐赠科研通 3270758
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882195
科研通“疑难数据库(出版商)”最低求助积分说明 809208