Neurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study

重性抑郁障碍 白质 心理学 双相情感障碍 磁共振弥散成像 磁共振成像 精神分裂症(面向对象编程) 神经科学 大脑大小 神经影像学 精神科 医学 认知 放射科
作者
Miao Chang,Fay Y. Womer,E. Kale Edmiston,Chuan Bai,Qian Zhou,Xiaowei Jiang,Shengnan Wei,Yange Wei,Yuting Ye,Haiyan Huang,Yong He,Ke Xu,Yanqing Tang,Fei Wang
出处
期刊:Schizophrenia Bulletin [Oxford University Press]
卷期号:44 (1): 65-74 被引量:78
标识
DOI:10.1093/schbul/sbx028
摘要

Background: Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site. Results: Significant 4-group (SZ, BD, MDD, and HC groups) differences (P < .05, corrected) in GM volumes were found primarily in the paralimbic and heteromodal corticies. Post hoc analyses showed that the SZ, BD, and MDD groups shared GM volume decreases in 87.9% of the total regional volume with significant 4-group differences. Significant 4-group differences in WM integrity (P < .05 corrected) were found in callosal, limbic-paralimbic-hetermodal, cortico-cortical, thalamocortical and cerebellar WM. Post hoc analyses revealed that the SZ and BD groups shared WM alterations in all regions, while WM alterations were not observed with MDD. Conclusions: Our findings of common alterations in SZ, BD, and MDD support the presence of core neurobiological disruptions in these disorders and suggest that neural structural distinctions between these disorders may be less prominent than initially postulated, particularly between SZ and BD.
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