化学
色谱法
乳酸
检出限
柱色谱法
杂质
离子色谱法
高效液相色谱法
分析化学(期刊)
有机化学
细菌
遗传学
生物
作者
Zhao Zhen,Jianzhong Zhu,Yanli Xie
标识
DOI:10.1016/j.jpba.2017.02.031
摘要
In this study, a simple and sensitive on-line pretreatment of column-switching technique coupled with ion chromatography method was achieved for the determination of key impurity of lactic acid in lobaplatin. The first dimension of reverse phase liquid chromatography was used to reduce organic matrices, whereas the second dimension of ion chromatography was applied for the separation and detection of lactic acid. The results exhibited good linearity (R = 0.9994) ranging from 0.01 mg L−1 to 50 mg L−1. The limit of detection was below 0.0015 mg L−1. Also, a spiking study was performed with satisfactory recoveries between 96% and 106%.
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