ESCRT公司
内体
AAA蛋白
膜
细胞生物学
胞质分裂
膜拓扑
化学
小泡
生物物理学
萌芽
胞浆
膜蛋白
拓扑(电路)
生物
ATP酶
细胞内
细胞
生物化学
细胞分裂
组合数学
酶
数学
作者
Johannes Schöneberg,Il‐Hyung Lee,Janet Iwasa,James H. Hurley
摘要
New observations of ESCRT-mediated reverse-topology membrane scission are building towards a structural and biophysical explanation of the mechanism involved. The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles. This 'reverse' (or 'inverse')-topology membrane scission is carried out by the endosomal sorting complex required for transport (ESCRT) proteins, which form filaments, flat spirals, tubes and conical funnels that are thought to direct membrane remodelling and scission. Their assembly, and their disassembly by the ATPase vacuolar protein sorting-associated 4 (VPS4) have been intensively studied, but the mechanism of scission has been elusive. New insights from cryo-electron microscopy and various types of spectroscopy may finally be close to rectifying this situation.
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