Fabrication of fibrillized collagen microspheres with the microstructure resembling an extracellular matrix

By controlling the interfacial properties of hydrophilic–lipophilic balance, surfactant concentration, rotor speed, inorganic salt, and temperature, fibrillized collagen microspheres possessing the same fibril structure as that of native tissue were prepared using water-in-oil (W/O) emulsion.