成骨细胞
钙
破骨细胞
细胞外
化学
体外
细胞生物学
矿化(土壤科学)
骨髓
内科学
内分泌学
生物
生物化学
医学
有机化学
氮气
作者
Yoichi Shirai,Yoshitaka Yoshimura,Yasutaka Yawaka,Tomokazu Hasegawa,Takashi Kikuiri,Sadaaki Takeyama,Akira Matsumoto,Haruhisa Oguchi
标识
DOI:10.1006/bbrc.1999.1664
摘要
We have been researching with the purpose of understanding the hard organization mineralization-suppression mechanism under a low calcium environment. So far, we have discerned clearly that the femur of an incubated newborn rat under a low calcium environment will develop bone formation dyscrasia such as hypertrophy of the caput. In this experiment, MC3T3-E1 (E1) cells, which are osteoblast-like cells, and mouse bone marrow were incubated in a coculture system under a low calcium environment and manifestation of osteoblast cells and their ability to resorb were examined. The results suggested that as the calcium concentration in the medium decreased manifestation of osteoclast cells increased, and as the degree of mineralization of E1 cells advanced, the number of manifestation of osteoblast cells decreased. We, therefore, report that there is a possibility that extracellular calcium concentrations involve the process of differentiation of bone marrow cells into osteoblast cells.
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