Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

咖啡酸 绿原酸 内分泌学 内科学 甘油三酯 化学 脂肪组织 脂联素 脂肪酸 脂质代谢 胰岛素 胰岛素抵抗 胆固醇 生物化学 生物 医学 食品科学 抗氧化剂
作者
Ae-Sim Cho,Seon-Min Jeon,Myung‐Joo Kim,Jiyoung Yeo,Kwon‐Il Seo,Myung‐Sook Choi,Mi‐Kyung Lee
出处
期刊:Food and Chemical Toxicology [Elsevier BV]
卷期号:48 (3): 937-943 被引量:740
标识
DOI:10.1016/j.fct.2010.01.003
摘要

This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0.02% (wt/wt) dose. Both caffeic acid and chlorogenic acid significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels compared to the high-fat control group. They also lowered triglyceride (in plasma, liver and heart) and cholesterol (in plasma, adipose tissue and heart) concentrations. Triglyceride content in adipose tissue was significantly lowered, whereas the plasma adiponectin level was elevated by chlorogenic acid supplementation compared to the high-fat control group. Body weight was significantly correlated with plasma leptin (r = 0.894, p < 0.01) and insulin (r = 0.496, p < 0.01) levels, respectively. Caffeic acid and chlorogenic acid significantly inhibited fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase activities, while they increased fatty acid β-oxidation activity and peroxisome proliferator-activated receptors α expression in the liver compared to the high-fat group. These results suggest that caffeic acid and chlorogenic acid improve body weight, lipid metabolism and obesity-related hormones levels in high-fat fed mice. Chlorogenic acid seemed to be more potent for body weight reduction and regulation of lipid metabolism than caffeic acid.
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