吉非替尼
表皮生长因子受体
肺癌
癌症研究
酪氨酸激酶
医学
表皮生长因子
酪氨酸激酶抑制剂
突变
生物
癌症
内科学
受体
基因
遗传学
作者
Thomas J. Lynch,Daphne W. Bell,Raffaella Sordella,Sarada Gurubhagavatula,Ross A. Okimoto,Brian W. Brannigan,Patricia L. Harris,Sara M. Haserlat,Jeffrey G. Supko,Frank G. Haluska,David N. Louis,David C. Christiani,Jeff Settleman,Daniel A. Haber
摘要
Most patients with non–small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms underlying sensitivity to gefitinib are unknown.
科研通智能强力驱动
Strongly Powered by AbleSci AI