An Investigation of Functional and Anatomical Connectivity Using Magnetic Resonance Imaging

白质 磁共振弥散成像 体素 灰质 功能连接 像素 功能磁共振成像 统计物理学 物理 人工智能 计算机科学 核磁共振 磁共振成像 模式识别(心理学) 神经科学 心理学 医学 放射科
作者
Martin Koch,David G. Norris,Margret Hund‐Georgiadis
出处
期刊:NeuroImage [Elsevier]
卷期号:16 (1): 241-250 被引量:479
标识
DOI:10.1006/nimg.2001.1052
摘要

This article examines functional and anatomical connectivity in healthy human subjects measured with magnetic resonance imaging methods. Anatomical connectivity in white matter is obtained from measurements of the diffusion tensor. A Monte-Carlo simulation determines the probability that a particle diffuses between two points, with the probability of a jump in a particular direction from a given voxel being based on the local value of the diffusion tensor components. Functional connectivity between grey matter pixels is assessed without recourse to a specific activation paradigm, by calculating the correlation coefficient between random fluctuations in the blood oxygenation level-dependent signal time course in different pixels. The methods are used to examine the anatomical and functional connectivities between crowns of adjacent gyri. A high functional connectivity was found between grey matter pixels, with white matter displaying only very low correlation. A comparison of the measurements of anatomical and functional connectivity found that there is no simple correlation between these measures, except that low values of functional connectivity were not found together with high values of anatomical connectivity. Furthermore pairs of regions situated around the central sulcus indicated a dependence of the two connectivity measures on each other. These results are in accordance with an interpretation that regions which are clearly directly linked by white matter fiber tracts should show high functional connectivity, but that the inverse need not be true as functional connectivity may also be indirectly mediated via more distant grey matter regions.
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