Left Renal Nerves Stimulation Facilitates Ischemia‐Induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion

医学 星状神经节 内科学 心脏病学 刺激 交感神经系统 心肌梗塞 动脉 去甲肾上腺素 麻醉 神经生长因子 血压 多巴胺 病理 受体 替代医学
作者
Bing Huang,Lilei Yu,Benjamin J. Scherlag,Songyun Wang,Bo He,Kang Yang,Kai Liao,Zhibing Lu,Wenbo He,Ling Zhang,Sunny S. Po,Hong Jiang
出处
期刊:Journal of Cardiovascular Electrophysiology [Wiley]
卷期号:25 (11): 1249-1256 被引量:51
标识
DOI:10.1111/jce.12498
摘要

Renal Sympathetic Nerves and Ventricular Arrhythmias Introduction Renal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI). Methods and Results Twenty‐eight dogs received 3 hours of continuous left‐sided electrical stimulation of RSN (LRS; Group‐1, n = 9), sham RSN stimulation (Group‐2, n = 9), or LSG ablation plus 3 hours of LRS (Group‐3, n = 10) were included. AMI was induced by ligating the proximal left anterior descending coronary artery. LRS was performed using electrical stimulation on the adventitia of left renal artery at the voltage increasing the systolic blood pressure (BP) by 10%. BP, heart rate variability (HRV), serum norepinephrine (NE) level, and LSG function were measured at baseline and the end of each hour of LRS. C‐fos and nerve growth factor (NGF) protein expressed in the LSG were examined in Group‐1 and Group‐2. Compared with baseline, 3 hours of LRS induced a significant increase in BP, sympathetic indices of HRV, serum NE level, and LSG function. The incidence of VAs in Group‐1 was significantly higher than other groups. The expression of c‐fos and NGF protein in the LSG was significantly higher in Group‐1 than Group‐2. Conclusion Three hours of LRS induces both systemic and cardiac sympathetic hyperactivity and increases the incidence of ischemia‐induced VAs.
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