Left Renal Nerves Stimulation Facilitates Ischemia‐Induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion

医学 星状神经节 内科学 心脏病学 刺激 交感神经系统 心肌梗塞 动脉 去甲肾上腺素 麻醉 神经生长因子 血压 多巴胺 病理 受体 替代医学
作者
Bing Huang,Lilei Yu,Benjamin J. Scherlag,Songyun Wang,Bo He,Kang Yang,Kai Liao,Zhibing Lu,Wenbo He,Ling Zhang,Sunny S. Po,Hong Jiang
出处
期刊:Journal of Cardiovascular Electrophysiology [Wiley]
卷期号:25 (11): 1249-1256 被引量:51
标识
DOI:10.1111/jce.12498
摘要

Renal Sympathetic Nerves and Ventricular Arrhythmias Introduction Renal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI). Methods and Results Twenty‐eight dogs received 3 hours of continuous left‐sided electrical stimulation of RSN (LRS; Group‐1, n = 9), sham RSN stimulation (Group‐2, n = 9), or LSG ablation plus 3 hours of LRS (Group‐3, n = 10) were included. AMI was induced by ligating the proximal left anterior descending coronary artery. LRS was performed using electrical stimulation on the adventitia of left renal artery at the voltage increasing the systolic blood pressure (BP) by 10%. BP, heart rate variability (HRV), serum norepinephrine (NE) level, and LSG function were measured at baseline and the end of each hour of LRS. C‐fos and nerve growth factor (NGF) protein expressed in the LSG were examined in Group‐1 and Group‐2. Compared with baseline, 3 hours of LRS induced a significant increase in BP, sympathetic indices of HRV, serum NE level, and LSG function. The incidence of VAs in Group‐1 was significantly higher than other groups. The expression of c‐fos and NGF protein in the LSG was significantly higher in Group‐1 than Group‐2. Conclusion Three hours of LRS induces both systemic and cardiac sympathetic hyperactivity and increases the incidence of ischemia‐induced VAs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉觅云应助东晓采纳,获得10
1秒前
1秒前
姜磊完成签到,获得积分20
2秒前
2秒前
xxddw发布了新的文献求助10
3秒前
3秒前
谢海洋完成签到,获得积分10
4秒前
5秒前
loski发布了新的文献求助10
6秒前
7秒前
xueyu发布了新的文献求助10
8秒前
9秒前
lincy完成签到,获得积分10
10秒前
fqk完成签到,获得积分10
10秒前
11秒前
hanleiharry1发布了新的文献求助10
11秒前
11秒前
13秒前
乐乐应助WN采纳,获得10
15秒前
辛勤的刺猬完成签到 ,获得积分10
19秒前
神奇宝贝发布了新的文献求助10
19秒前
19秒前
丘比特应助sssyq采纳,获得10
20秒前
20秒前
芝麻福福完成签到,获得积分10
20秒前
FYm完成签到,获得积分10
21秒前
心灵美孤菱完成签到,获得积分10
21秒前
田様应助阳光怀亦采纳,获得50
22秒前
阿牛哥关注了科研通微信公众号
23秒前
zsl完成签到,获得积分10
25秒前
26秒前
东晓发布了新的文献求助10
26秒前
娴娴完成签到,获得积分10
27秒前
hanleiharry1发布了新的文献求助10
28秒前
乖猫要努力应助pppp采纳,获得10
28秒前
Akim应助坚强的严青采纳,获得10
28秒前
29秒前
29秒前
31秒前
科目三应助旧梦采纳,获得10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174