An improved synthesis of 6-O-monotosyl-6-deoxy-β-cyclodextrin

Addition of p-toluenesulfonic anhydride (Ts2O) to β-cyclodextrin (CD) in water, followed by treatment with 10% aqueous NaOH solution for 10 min and removal of excess Ts2O by filtration, gave mono-6-deoxy-6-(O-p-toluenesulfonyl)-CD (1) in 61% yield.