A Versatile New Preparation of Cyclopropylamines from Acid Dialkylamides

The reaction of acid N,N-dialkylamides with alkylmagnesium bromides in the presence of a stoichiometric amount of titanium tetra(2-propanolate) produces dialkylcyclopropylamines like 1 and 2 in moderate to good yields. Previously inaccessible aminocyclopropane derivatives are now readily available.