多路复用
计算生物学
磁珠
药物发现
有孔小珠
计算机科学
纳米技术
生物
化学
生物信息学
材料科学
色谱法
复合材料
作者
Boon‐ek Yingyongnarongkul,Siew Eng How,Juan José Díaz‐Mochón,Mathilde Muzerelle,Mark Bradley
出处
期刊:Combinatorial Chemistry & High Throughput Screening
[Bentham Science]
日期:2003-11-01
卷期号:6 (7): 577-587
被引量:26
标识
DOI:10.2174/138620703771981179
摘要
Advances in high throughput screening (HTS), together with the rapid progress in combinatorial chemistry, genomic and proteomic sciences have dramatically stimulated the development of a variety tools to enable the drug discovery process to become more efficient. Major future challenges in HTS include obtaining high density and good quality data based on assays that are rapid, reliable, inexpensive, sensitive, simple and miniaturised. This paper reviews the development and role of bead-based assays for HTS including DNA and single nucleotide polymorphism (SNP) assays, particularly from a multiplex perspective and evaluating the recent advances in bead-based arrays. The encoding strategies that are commonly used in bead-based assays are highlighted, while the importance of magnetic beads in genomic and proteomic purifications is discussed. In conclusion, bead-based assays offer a powerful promising approach for many aspects of drug discovery.
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