5-羟甲基胞嘧啶
表观基因组
表观遗传学
DNA甲基化
生物
后生
表观遗传学
计算生物学
DNA
遗传学
5-甲基胞嘧啶
基因
基因表达
作者
Miguel R. Branco,Gabriella Ficz,Wolf Reik
摘要
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
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