盐酸二甲双胍
茚三酮
二甲双胍
色谱法
盐酸盐
化学
剂型
医学
有机化学
氨基酸
生物化学
内科学
胰岛素
作者
G. Mubeen,Khalikha Noor
标识
DOI:10.4103/0250-474x.51947
摘要
A simple and sensitive spectrophotometric method has been developed and validated for the estimation of metformin hydrochloride in bulk and in tablet formulation. The primary amino group of metformin hydrochloride reacts with ninhydrin in alkaline medium to form a violet colour chromogen, which is determined spectrophotometrically at 570 nm. It obeyed Beer's law in the range of 8-18 mug/ml. Percentage recovery of the drug for the proposed method ranged from 97-100% indicating no interference of the tablet excipients. The proposed method was found to be accurate and precise for routine estimation of metformin hydrochloride in bulk and from tablet dosage forms.
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