Thoracic Air-leak Syndromes In Hematopoietic Stem Cell Transplant Recipients with Graft-versus-Host Disease: A Possible Sign for Poor Response to Treatment and Poor Prognosis

医学 外科 闭塞性细支气管炎 并发症 闭塞性细支气管炎机化性肺炎 造血干细胞移植 心包积气 胃肠病学 移植 内科学 肺移植
作者
Mi Hyoung Moon,Young Jo,Kyu Do Cho,Keon Hyon Jo,Sun Hee Lee,Sung Bo Sim
出处
期刊:Journal of Korean Medical Science [Korean Academy of Medical Sciences]
卷期号:25 (5): 658-658 被引量:39
标识
DOI:10.3346/jkms.2010.25.5.658
摘要

Bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP) is one of manifestations of graft-versus-host disease (GVHD), a complication of hematopoietic stem cell transplantation (HSCT). Recently there are reports about thoracic air-leakage syndrome (TALS), but real incidence, clinical course, and implications of TALS remain unclear. Retrospective review of 18 TALS patients among 2,177 patients who received allogeneic HSCT between January 2000 to July 2007 was done. Clinical manifestations, treatments, and outcomes of TALS were reviewed. The incidence of TALS was 0.83% (18/2,177). The onset of TALS was mean 425.9+/-417.8 days (60-1,825 days) after HSCT, and the duration was mean 16.3+/-21 days (2-90 days). The most common types of TALS were spontaneous pneumothroax (n=14), followed by subcutaneous emphysema (n=6), pneumomediastinum (n=5), interstitial emphysema (n=2), and pneumopericardium (n=1). TALS persisted in six patients, who died during the same hospitalization. The 12 patients recovered from TALS, but only 2 survived, while others died due to aggravation of GVHD. TALS may complicate BO/BOOP and be an initial manifestation of BO/BOOP. TALS is hard to be resolved, and even after the recovery, patients die because of aggravation of GVHD. We suggest specifically in HSCT patients, when once developed, TALS seems hard to be cured, and as a result, be related to high fatality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
共享精神应助huhu采纳,获得10
刚刚
立追拓完成签到,获得积分10
刚刚
1秒前
1秒前
1秒前
思源应助uu采纳,获得10
2秒前
杨qian完成签到,获得积分10
2秒前
Joy发布了新的文献求助10
3秒前
nsk发布了新的文献求助10
3秒前
3秒前
万能图书馆应助包容诗云采纳,获得10
3秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
tianzml0应助科研通管家采纳,获得10
4秒前
CipherSage应助科研通管家采纳,获得30
4秒前
在水一方应助科研通管家采纳,获得10
4秒前
拼搏小丸子完成签到 ,获得积分10
4秒前
4秒前
LCW07发布了新的文献求助10
4秒前
4秒前
tianzml0应助科研通管家采纳,获得10
4秒前
小马甲应助科研通管家采纳,获得10
4秒前
Owen应助科研通管家采纳,获得10
4秒前
iNk应助科研通管家采纳,获得10
4秒前
jyx应助科研通管家采纳,获得10
4秒前
跳跃寄柔发布了新的文献求助10
4秒前
4秒前
田様应助科研通管家采纳,获得10
4秒前
王小兵发布了新的文献求助30
5秒前
科研通AI2S应助鲤鱼小熊猫采纳,获得10
5秒前
酷波er应助Xiang采纳,获得10
5秒前
杨qian发布了新的文献求助10
5秒前
李爱国应助点墨采纳,获得10
6秒前
Snow发布了新的文献求助10
7秒前
7秒前
7秒前
美丽柠檬完成签到,获得积分10
8秒前
superxiao完成签到,获得积分0
8秒前
8秒前
CipherSage应助gyyyy采纳,获得10
9秒前
李有钱发布了新的文献求助10
11秒前
高分求助中
Lire en communiste 1000
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 800
Becoming: An Introduction to Jung's Concept of Individuation 600
中国氢能技术发展路线图研究 500
Communist propaganda: a fact book, 1957-1958 500
Briefe aus Shanghai 1946‒1952 (Dokumente eines Kulturschocks) 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3168110
求助须知:如何正确求助?哪些是违规求助? 2819468
关于积分的说明 7926640
捐赠科研通 2479343
什么是DOI,文献DOI怎么找? 1320739
科研通“疑难数据库(出版商)”最低求助积分说明 632898
版权声明 602458