基因组印记
生物
印记(心理学)
表观遗传学
重编程
DNA甲基化
遗传学
染色质
基因
组蛋白
进化生物学
表观遗传学
基因组
X-失活
基因表达
计算生物学
X染色体
作者
Denise P. Barlow,Marisa S. Bartolomei
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2014-02-01
卷期号:6 (2): a018382-a018382
被引量:467
标识
DOI:10.1101/cshperspect.a018382
摘要
Genomic imprinting affects a subset of genes in mammals and results in a monoallelic, parental-specific expression pattern. Most of these genes are located in clusters that are regulated through the use of insulators or long noncoding RNAs (lncRNAs). To distinguish the parental alleles, imprinted genes are epigenetically marked in gametes at imprinting control elements through the use of DNA methylation at the very least. Imprinted gene expression is subsequently conferred through lncRNAs, histone modifications, insulators, and higher-order chromatin structure. Such imprints are maintained after fertilization through these mechanisms despite extensive reprogramming of the mammalian genome. Genomic imprinting is an excellent model for understanding mammalian epigenetic regulation.
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