阿斯巴甜
化学
毒性
内分泌学
苯丙氨酸
内科学
泌尿系统
口服
尿
排泄
钙
氨基酸
医学
生物化学
作者
Hiroyuki Ishii,Toshio Koshimizu,Shuji Usami,Tsumoru Fujimoto
出处
期刊:Toxicology
[Elsevier]
日期:1981-01-01
卷期号:21 (2): 91-94
被引量:54
标识
DOI:10.1016/0300-483x(81)90119-0
摘要
Aspartame (APM) or L-aspartyl-L-phenylalanine, and a 3 : 1 combination of APM with its decomposition product, 5-benzyl-3,6-dioxo-2-piperazine acetic acid (DKP), were incorporated at levels of up to 4 g/kg in the diet of male and female Wistar rats from 6 weeks to 104 weeks of age. There was a dose-dependent depressionby body weight gain at 2 and 4 g/kg AMP and at 4 g/kg APM + DKP in males, and at all dose levels in females, correlated with decreased food consumption and attributed to liberation of amino acids from hydrolysis of APM. Increases in urinary specific gravity and pH, with increase of relative kidney weight, were attributed to the urinary excretion of DKP and acidic metabolites of APM. A dose-related increase in urinary calcium probably reflected increased calcium absorption, as from high protein diets. A slight decrease in serum cholesterol and an increase in relative spleen weight appeared to be without adverse effect. It is concluded that the treatments were without toxic effect.
科研通智能强力驱动
Strongly Powered by AbleSci AI