Elevated thromboxane B2 levels in periodontal disease

Thromboxane B 2 , the stable end product of thromboxane A 2 , was measured by a sensitive radioimmunoassay in gingival tissue obtained from clinically normal beagle dogs and beagle dogs with gingivitis and periodontitis. The animals with gingivitis contained gingival thromboxane B 2 levels nearly twice that of clinically normal gingiva, while animals with periodontitis revealed gingival levels of thromboxane B 2 that were 3–1/2 times greater than clinically normal and twice that of dogs with gingivitis.