受体
G蛋白偶联受体
第二信使系统
溶血磷脂酰胆碱
亚科
生物
G蛋白
脂质信号
化学
细胞生物学
神经科学
生物化学
基因
磷脂
膜
磷脂酰胆碱
作者
Klaus Seuwen,Marie‐Gabrielle Ludwig,Romain M. Wolf
标识
DOI:10.1080/10799890600932220
摘要
The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine. We challenged this view by reporting that OGR1 and GPR4 sense acidic pH and that this process is not affected by concentrations of SPC or LPC previously reported as agonistic. The original publications describing GPR4, OGR1, and G2A as receptors for LPC or SPC have now been retracted, and the first studies exploring receptors of this family as pH sensors in physiology have appeared. Here we review the status of this field and we confirm that GPR4, OGR1, and TDAG8 should be considered as proton-sensing receptors. Negative regulation of these receptors by high micromolar concentrations of lipids appears not specific in our experiments.
科研通智能强力驱动
Strongly Powered by AbleSci AI