Synthesis of New Xanthene Derivatives with Expected Antischistosomal Activity

Abstract N ‐(9 H ‐Xanthen‐9‐yl)succinimide ( 1 ) is prepared by the reaction of xanthene with N ‐bromosuccinimide. Hydrolysis of 1 with 5% NaOH yields 3‐[(9 H ‐xanthen‐9‐yl)aminocarbonyl]propionic acid ( 3a ). The corresponding methyl ester 3c is obtained from 3a by the action of diazomethane. The butanol derivative 4a can be obtained by reduction of 3a or 3c with LiAlH 4 . Treatment of 1 with LiAlH 4 yields the pyrrolidine derivative 5 . N ‐(9 H ‐Xanthen‐9‐yl)phthalimide ( 2 ) undergoes similar reactions like its analogue 1 .