A quaternary composite fiber membrane for guided tissue regeneration

This work reported a novel composite fiber membrane containing poly(1actic-co-glycolic acid)/six-armed poly(ε-caprolactone)/hydroxylapatite-grafted poly(l-lactide)/Pluronic F-108 (PLGA/SAPCL/HA-g-PLLA/PF-108) produced by electrospinning. SAPCL, HA-g-PLLA, and PF-108 could be well blended with PLGA to make fibers. Fibrous surface and diameter had little difference in morphology with the change of fibrous component. Compared with simple PLGA, PLGA/SAPCL, or PLGA/SAPCL/HA-g-PLLA fiber membrane, the quaternary composites not only showed the improved mechanics stability but also possessed better hydrophilicity. The quaternary membrane was conductive to accelerate degradation and maintained nice bioactivity. It was not cytotoxicity. These results suggest that the composite fiber membrane may be qualified as guided bone regeneration substrate. Copyright © 2015 John Wiley & Sons, Ltd.