纳米载体
材料科学
沸石咪唑盐骨架
姜黄素
赫拉
纳米技术
咪唑酯
药物输送
细胞毒性
纳米医学
纳米颗粒
纳米尺度
金属有机骨架
有机化学
化学
体外
生物化学
吸附
作者
Min Zheng,Shi Liu,Xingang Guan,Zhigang Xie
标识
DOI:10.1021/acsami.5b04315
摘要
A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
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