重编程
抽搐
表型
间充质干细胞
上皮-间质转换
癌症研究
转移
癌症
表观遗传学
生物
癌细胞
细胞生物学
化学
遗传学
细胞
神经科学
基因
作者
Diwakar R. Pattabiraman,Brian Bierie,Katharina Isabelle Kober,Prathapan Thiru,Jordan A. Krall,Christina Zill,Ferenc Reinhardt,Wai Leong Tam,Robert A. Weinberg
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-03-04
卷期号:351 (6277)
被引量:236
标识
DOI:10.1126/science.aad3680
摘要
Have cancer stem cells MET their match? Solid tumors have been hypothesized to contain a subset of highly aggressive cells that fuel tumor growth and metastasis. The search is on for drugs that selectively kill or diminish the malignant properties of these tumor-initiating cells (TICs; previously called “cancer stem cells”). Pattabiraman et al. hypothesized that compounds that induce TICs to undergo a phenotypic change called the mesenchymal-to-epithelial transition (MET) would therefore cause TICs to lose their tumor-initiating ability. Indeed, drugs activating the protein kinase A signaling pathway triggered an epigenetic reprogramming of TICs that resulted in the cells acquiring a more benign epithelial-like phenotype. Science , this issue p. 10.1126/science.aad3680
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