Corrected QT interval prolongation in anthracycline-treated survivors of childhood cancer.

医学 蒽环类 QT间期 内科学 肿瘤科 延长 曲妥珠单抗 癌症 乳腺癌
作者
Claire Schwartz,Wendy L. Hobbie,Susie C. Truesdell,L C Constine,E. B. Clark
出处
期刊:Journal of Clinical Oncology [Lippincott Williams & Wilkins]
卷期号:11 (10): 1906-1910 被引量:96
标识
DOI:10.1200/jco.1993.11.10.1906
摘要

PURPOSE Comprehensive cardiac evaluations are currently recommended for all anthracycline-treated patients to detect subclinical cardiac failure. A screening test is needed that would easily and inexpensively identify patients who are at risk for late cardiac decompensation. METHODS We routinely reviewed the ECG and echocardiogram (ECHO) results of 52 of 56 anthracycline-treated long-term survivors of childhood cancer who had received > or = 100 mg/m2 of ANTH (ANTH = 1 mg/m2 of doxorubicin), and who were not in clinical heart failure. Exercise testing was performed in eight patients with a corrected QT interval (QTc) of > or = 0.43. RESULTS Zero of 15 patients (without chest radiation) who received less than 300 mg/m2 of ANTH versus six of 22 who received > or = 300 mg/m2 of ANTH had a QTc > or = 0.43 (P = .03). Three of 15 patients (with chest radiation) who received less than 300 mg/m2 of ANTH versus 12 of 22 who received > or = 300 mg/m2 of ANTH had a QTc > or = 0.43 (P = .03). For all patients (including those with chest radiotherapy), zero of 19 who received less than 300 mg/m2 of ANTH versus eight of 33 who received > or = 300 mg/m2 of ANTH had a QTc of > or = 0.45 (P = .025). Three of 19 who received less than 300 mg/m2 of ANTH versus 19 of 33 who received > or = 300 mg/m2 of ANTH had a QTc of > or = 0.43 (P = .003). One patient had decreased fractional shortening (FS) and QTc prolongation. Cardiac decompensation (with a FS of 24%) occurred with propranolol in a patient with previously normal FS but prolonged QTc. With exercise, the QTc became further prolonged in all four patients with a QTc of 0.44 to 0.46 and in two of four patients with a QTc of 0.43. CONCLUSION Prolongation of the QTc, a measure of myocardial repolarization, may reflect injury to myocardial cells. QTc prolongation may be predictive of an increased risk of late cardiac decompensation. If the utility of the QTc measure is confirmed, screening for evidence of myocardial damage can be easily and inexpensively performed by oncologists and primary caretakers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
噜噜噜噜噜完成签到,获得积分10
刚刚
赵慧霞关注了科研通微信公众号
刚刚
炎魔之王拉格纳罗斯完成签到,获得积分10
1秒前
内向苡完成签到,获得积分10
2秒前
以筱发布了新的文献求助10
4秒前
bhkwxdxy完成签到,获得积分10
5秒前
悦耳虔纹完成签到 ,获得积分10
5秒前
xx完成签到,获得积分10
5秒前
大气灵枫完成签到,获得积分10
5秒前
妮妮完成签到,获得积分10
6秒前
8秒前
Struggle完成签到 ,获得积分10
9秒前
9秒前
秦兴虎完成签到,获得积分10
10秒前
Drew11完成签到,获得积分10
10秒前
风趣青槐完成签到,获得积分10
12秒前
科隆龙完成签到,获得积分10
13秒前
13秒前
饱满一手完成签到 ,获得积分10
13秒前
99完成签到,获得积分10
15秒前
枕星发布了新的文献求助10
15秒前
drlq2022完成签到,获得积分10
16秒前
王山完成签到,获得积分10
17秒前
自觉寒梦完成签到,获得积分10
18秒前
ding应助缥缈一刀采纳,获得10
18秒前
pakiorder发布了新的文献求助10
18秒前
专心搞学术完成签到,获得积分10
18秒前
bkagyin应助zzcherished采纳,获得10
20秒前
你怎么这么可爱啊完成签到,获得积分10
20秒前
21秒前
研友_Lmg1gZ完成签到,获得积分10
21秒前
Crazyer完成签到,获得积分10
21秒前
Shuey完成签到,获得积分10
22秒前
XXXXH完成签到,获得积分10
22秒前
Z可完成签到 ,获得积分10
23秒前
momo123完成签到 ,获得积分10
23秒前
高兴的书竹完成签到 ,获得积分10
24秒前
mp5完成签到,获得积分10
25秒前
薯条一克完成签到 ,获得积分10
25秒前
zzcherished完成签到,获得积分10
26秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029