医学
前列腺切除术
曲普瑞林
佐剂
泌尿科
醋酸环丙孕酮
前列腺癌
环丙孕酮
外科
恶性肿瘤
激素
抗雄激素
内科学
癌症
雄激素
促黄体激素
促性腺激素释放激素
作者
Jonas Hugosson,Per‐Anders Abrahamsson,Göran Ahlgren,G. Aus,Susanne Lundberg,Sonny Schelin,Moddy Schain,K Pedersen
摘要
To investigate the outcome of neo-adjuvant hormone treatment before radical prostatectomy regarding local tumour extension, peri-operative blood loss and operation time.Of 111 surgically treated patients with prostate cancer (T1b-T3a, N0, M0, G1-3), 55 were randomised to immediate radical prostatectomy and 56 to 3 months of neo-adjuvant treatment with triptorelin (3.75 mg i.m. every 28 days) and cyproterone acetate (50 mg b.i.d. for 3 weeks to prevent flare).No differences were found in blood loss or operation time but patients who had neo-adjuvant treatment had a significantly lower frequency of positive margins (41 vs. 23%, p = 0.013).Neo-adjuvant treatment does not facilitate radical prostatectomy but may improve the chance of local cure. This must, however, be documented with long-term follow-up in randomised patients.
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