生物膜
微生物学
白霉素类
生物
白色念珠菌
流出
抗药性
抗菌剂
胞外聚合物
抗真菌药
铜绿假单胞菌
抗真菌
细菌
两性霉素B
生物化学
卡斯波芬金
遗传学
作者
Pinku Mukherjee,Jyotsna Chandra
标识
DOI:10.1016/j.drup.2004.09.002
摘要
Device-related infections in most nosocomial diseases can be traced to the formation of biofilms (microbial communities encased within polysaccharide-rich extracellular matrix) by pathogens on surfaces of these devices. Candida species are the most common fungi isolated from these infections, and biofilms formed by these fungal organisms are associated with drastically enhanced resistance against most antimicrobial agents. This enhanced resistance contributes to the persistence of this fungus despite antifungal therapy. Candida biofilms exhibit enhanced resistance against most antifungal agents, except echinocandins and lipid formulations of AmB. The expression of drug efflux pumps during the early phase of biofilm formation and alterations in membrane sterol composition contribute to resistance of these biofilms against azoles. Metabolic dormancy and ECM do not appear to contribute to resistance, although in a mixed-species biofilm, ECM does retard the diffusion of drugs across biofilm. These multifactorial mechanisms of resistance in fungal biofilms constitute a broad-spectrum defense that is effective against many types of antifungal agents, and represent a common theme present across microbial biofilms.
科研通智能强力驱动
Strongly Powered by AbleSci AI